Development of Novel Non-invasive Contrast Agents for Contrast-Enhanced MicroCT of Biological Tissues — ICTMS Committee Dep of Applied Maths Australian National University
  1. Schedule
  2. Biological and biomedical structures
  3. Theme 3: Biological Materials, Cultural Heritage, and Batteries
  4. Development of Novel Non-invasive Contrast Agents for Contrast-Enhanced MicroCT of Biological Tissues

Development of Novel Non-invasive Contrast Agents for Contrast-Enhanced MicroCT of Biological Tissues (53)

Sarah Vangrunderbeeck 1 2 3 , Sébastien de Bournonville 1 4 , Hong Giang Ly Thi 5 , Greet Kerckhofs 1 2 6 , Wim De Borggraeve 3 , Tatjana Parac-Vogt 5
  1. Prometheus, Division of Skeletal Tissue Engineering, KU Leuven, Leuven, Belgium
  2. Biomechanics Lab, Institute of Mechanics, Materials and Civil Engineering, UCLouvain, Louvain-la-Neuve, Belgium
  3. Molecular Design and Synthesis, Department of Chemistry, KU Leuven, Leuven, Belgium
  4. Biomechanics Section, Department of Mechanical Engineering, KU Leuven, Leuven, Belgium
  5. Laboratory of Bioinorganic Chemistry, Department of Chemistry, KU Leuven, Leuven, Not US or Canada, Belgium
  6. Department of Materials Engineering, KU Leuven, Leuven, Not US or Canada, Belgium

 The combined use of contrast staining agents and X-ray microfocus computed tomography (microCT), referred to as contrast-enhanced X-ray microCT (CE-CT), can provide a solution for ex vivo 3D multi-tissue imaging of biological tissues. While many reported contrast agents (CAs) are destructive for the samples or toxic, we screened and validated different Wells-Dawson polyoxometalate formulations for visualization of biological tissues using CE-CT.

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